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The Music of Life: Biology Beyond Genes, by Denis Noble
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The gene's eye view of life, proposed in Richard Dawkins acclaimed bestseller The Selfish Gene, sees living bodies as mere vehicles for the replication of genetic codes. But in The Music of Life, world renowned physiologist Denis Noble argues that, to truly understand life, we must look beyond the "selfish gene" to consider life on a much wider variety of levels.
Life, Noble asserts, is a kind of music, a symphonic interplay between genes, cells, organs, body, and environment. He weaves this musical metaphor throughout this personal and deeply lyrical work, illuminating ideas that might otherwise be daunting to non-scientists. In elegant prose, Noble sets out a cutting-edge alternative to the gene's eye view, offering a radical switch of perception in which genes are seen as prisoners and the organism itself is a complex system of many interacting levels. In his more expansive view, life emerges as a process, the ebb and flow of activity in an intricate web of connections. He introduces readers to the realm of systems biology, a field that has been growing in strength in the past decade. Noble, himself one of the founders of this field, argues modern systems biology may be the view we need to adopt to gain a deeper understanding of the nature of life.
Drawing on his experiences in his research on the heartbeat, and on evolutionary biology, development, medicine, philosophy, linguistics, and Chinese culture, Noble presents us with a profound and very modern reflection on the nature of life.
- Sales Rank: #198316 in Books
- Published on: 2008-04-07
- Original language: English
- Number of items: 1
- Dimensions: 7.74" h x .49" w x 5.05" l, .32 pounds
- Binding: Paperback
- 176 pages
Review
`Review from previous edition A beautifully written book... After the great successes of molecular biology, the time has come to re-assemble the organism. Denis Noble tells us why this needs to be done. He also tells us how we should go about it. Strongly recommended. ' Sir Patrick Bateson, F.R.S., Emeritus Professor of Ethology, Cambridge
`highly evocative essay' Steven Poole, The Guardian
About the Author
Denis Noble is Emeritus Professor of Cardiovascular Physiology at the University of Oxford. He was Chairman of the International Union of Physiological Sciences World Congress in 1993, and Secretary-General of IUPS from 1993-2001.
Most helpful customer reviews
31 of 32 people found the following review helpful.
Small in size; big on ideas
By Steve Benner
Denis Noble describes his short book, "The Music of Life: Biology Beyond Genes", as a polemic. It is, in fact, a clarion call for a rethink to the reductionist dogmas that currently plague--and hinder--so much scientific thinking, particularly in the field of biology and, most especially, genetics. Professor Noble is not, of course, alone in making this call (see, for instance, Stuart Kaufmann's "Reinventing the Sacred" or "Evolution in Four Dimensions" by Eva Jablonka and Marion J. Lamb) but he presents a particularly clear-sighted argument which few others have so far matched. His is a far-reaching and eminently readable disquisition, attacking first the popular metaphor articulated primarily by Richard Dawkins in "The Selfish Gene" (and promulgated endlessly--usually incorrectly--by science popularists ever since) that genes are the engines of evolution and each genome a comprehensive "program of life". Throughout his book, Noble turns that view around with a different and far more accurate metaphor, presenting the genome as a database from which the organism can select in order to call upon an elegant modularity of gene expression in a bewildering display of inventiveness of response to environmental and physiological conditions.
Along the way, the author uses a series of music-related analogies to extend his metaphor and piece together the various fragments of his argument into a coherent look at the biology of the organism as a fully functioning system, operating on and at many levels. He shows that far from the established view where the arrows of explanation all point downwards to the lower, ever more fundamental elements of cellular physiology (ending up ultimately at DNA as the primary explanatory element) there exists in reality a complex system of feedback pathways which enable the organism to act upon its own genetic material, altering the way that each gene is expressed in combination with others as a consequence of their whereabouts within the organism, or the conditions to which the organism may be subjected. Within this systems view of biological functioning, the complex pathways of interaction become the primary explanatory elements, rather than any of the physical components themselves.
This single insight provides several additional mechanisms for the operation of evolution through natural selection over and above the simplistic one of random gene mutation which is held in such high regard by today's neo-Darwinists, and reopens the door to the long-ridiculed notion of so-called Lamarckian inheritance of acquired characteristics. It also calls into question the wisdom of, for instance, neurologists seeking the physical location of "the self" within the prescient organism; within Noble's view of things, such concepts as "the self" cease to have any likelihood of an actual physical presence (as separate, identifiable entities within the organism) but instead become emergent functional properties of a level of operation of the biological system itself.
It should be clear by now that this book presents serious challenges to a great deal of current biological dogma and there will be many readers for whom this book is an eye-opener. It is an easy and entertaining read for anyone with even a smattering of science and regardless of whether or not you finally come to agree with Denis Noble, you can be sure you'll find what he has to say interesting and enlightening.
0 of 0 people found the following review helpful.
Five Stars
By Lindsey
I was required to get this book for school!
19 of 19 people found the following review helpful.
Finally someone with knowledge and common (scientific) sense!
By Damir Janigro
Dr. Noble is one of the most creative physiologists of our time, and not surprisingly he decided to put an end to the endless "DNA craze" affecting scientists and media alike. In an era where everything is "genetic", Dr. Noble lucidly unmasks the pitfalls of gene-centrism, to reveal the powerful and obvious societal and organismal influences that govern gene expression. This little book does not deny the work by Dawkins and Gould (frequently and appropriately cited) but rather redefines the modern Darwinism of life in a more holistic, and scientifically acceptable perspective. The devil is in the details, and we have been fooled for too long by those who only see the music notation of life and not the whole symphony!
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